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Fecal Calprotectin at Postinduction Is Capable of Predicting Persistent Remission and Endoscopic Healing after 1 Year of Treatment with Infliximab in Pediatric Patients with Crohn's Disease

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Author(s)
Yoo Min LeeEun Sil KimSujin ChoiHyo-Jeong JangYu Bin KimSo Yoon ChoiByung-Ho ChoeBen Kang
Keimyung Author(s)
Jang, Hyo Jeong
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Gut Liver
Issued Date
2024
Volume
18
Issue
3
Keyword
CalprotectinCrohn diseaseInfliximabPrognosis
Abstract
Background/aims:
The recent update on Selecting Therapeutic Targets in Inflammatory Bowel Disease initiative has added a decrease in fecal calprotectin (FC) to an acceptable range as an intermediate target for Crohn's disease (CD). We aimed to investigate whether postinduction FC could predict future persistent remission (PR) and endoscopic healing (EH) after 1 year of treatment with infliximab (IFX) in pediatric patients with CD.

Methods:
This multicenter retrospective observational study included pediatric patients with CD who were followed up for at least 1 year after starting IFX. The association of postinduction FC with PR and EH was investigated.

Results:
A total of 132 patients were included in this study. PR and EH were observed in 71.2% (94/132) and 73.9% (82/111) of the patients, respectively. In multivariate logistic regression analysis, only the postinduction FC level was associated with PR (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.08 to 0.66; p=0.009). The FC levels at initiation of IFX and postinduction were significantly associated with EH (OR, 0.73; 95% CI, 0.53 to 0.99; p=0.044 and OR, 0.20; 95% CI, 0.06 to 0.49; p=0.002, respectively). According to the receiver operating characteristic curve analysis, the optimal cutoff level for postinduction FC associated with PR was 122 mg/kg, and that associated with EH was 377 mg/kg.

Conclusions:
Postinduction FC was associated with PR and EH after 1 year of treatment with IFX in pediatric patients with CD. Our findings emphasize the importance of FC as an intermediate target in the treat-to-target era.
Keimyung Author(s)(Kor)
장효정
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2005-1212
Source
https://www.gutnliver.org/journal/view.html?doi=10.5009/gnl230022
DOI
10.5009/gnl230022
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45481
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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