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Dysfunction of the Neurovascular Unit by Psychostimulant Drugs

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Author(s)
Tam Thuy Lu VoDain ShinEunyoung HaJi Hae Seo
Keimyung Author(s)
Ha, Eun YoungSeo, Ji Hye
Department
Dept. of Biochemistry (생화학)
Journal Title
Int J Mol Sci
Issued Date
2023
Volume
24
Issue
20
Keyword
blood–brain barrier (BBB)drug abuseneurodegenerationneuroinflammation: psychostimulant drugsneurovascular unit (NVU)
Abstract
Drug abuse' has been recognized as one of the most pressing epidemics in contemporary society. Traditional research has primarily focused on understanding how drugs induce neurotoxicity or degeneration within the central nervous system (CNS) and influence systems related to reward, motivation, and cravings. However, recent investigations have increasingly shifted their attention toward the detrimental consequences of drug abuse on the blood-brain barrier (BBB). The BBB is a structural component situated in brain vessels, responsible for separating brain tissue from external substances to maintain brain homeostasis. The BBB's function is governed by cellular interactions involving various elements of the 'neurovascular unit (NVU),' such as neurons, endothelial cells, astrocytes, pericytes, and microglia. Disruption of the NVU is closely linked to serious neurodegeneration. This review provides a comprehensive overview of the harmful effects of psychostimulant drugs on the BBB, highlighting the mechanisms through which drugs can damage the NVU. Additionally, the review proposes novel therapeutic targets aimed at protecting the BBB. By understanding the intricate relationships between drug abuse, BBB integrity, and NVU function, researchers and clinicians may uncover new strategies to mitigate the damaging impact of drug abuse on brain health.
Keimyung Author(s)(Kor)
하은영
서지혜
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1422-0067
Source
https://www.mdpi.com/1422-0067/24/20/15154
DOI
10.3390/ijms242015154
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45492
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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