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Analysis of single umbilical artery with concurrent congenital anomaly: Is it a risk factor for poor prognosis? A cross-sectional study

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Author(s)
Na Hyun LeeHee Joung Choi
Keimyung Author(s)
Choi, Hee Joung
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Int J Reprod Biomed
Issued Date
2024
Volume
22
Issue
2
Keyword
Congenital abnormalitiesPerinatal mortality.Single umbilical artery
Abstract
Background:
A single umbilical artery (SUA) may coexist with a single anomaly or multiple congenital anomalies. Although anomalies associated with SUA can primarily cause high perinatal mortality, their clinical significance has not been evaluated.

Objective:
We investigated the relationship between the clinical features and the type or number of concurrent anomalies in neonates with SUA.

Materials and methods:
In this cross-sectional study, 104 neonates with SUA were enrolled from January 2000 to December 2020 at Dongsan hospital, Daegu, South Korea. Data on the maternal history and the neonates demographic characteristics, clinical course, chromosomal analysis, and congenital anomalies, were collected.

Results:
Among the neonates with SUA included, 77 (74.0%) had one or more congenital anomalies; 66 (63.5%) were cardiac, 20 (19.2%) were genitourinary, 12 (11.5%) were gastrointestinal, 5 (4.8%) were central nervous system, 12 (11.5%) were skeletal, and 5 (4.8%) were facial anomalies. The number of concurrent anomalies ranged from 0-4. Neonates with SUA and concurrent gastrointestinal anomaly had a high incidence of initial positive ventilation, intubation, and inotropic drug use and lower Apgar score at 1 min and 5 min. 7 (6.7%) neonates with SUA died. Low birth weight (odds ratio = 6.16, p = 0.05), maternal multiparity (2.41, p = 0.13), gastrointestinal anomaly (5.06, p = 0.11), and initial cardiac resuscitation (7.77, p = 0.11) were risk factors for mortality in neonates with SUA.

Conclusion:
Neonates with SUA and concurrent gastrointestinal anomaly, low birth weight, maternal multiparity, and initial cardiac resuscitation had poor outcomes.
Keimyung Author(s)(Kor)
최희정
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2476-3772
Source
https://ijrm.ir/article-1-2647-en.html
DOI
10.18502/ijrm.v22i2.15710
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45494
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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