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Recurrence after postoperative intravesical instillation therapy in Hunner type interstitial cystitis

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Author(s)
Kwang Jin KoMichael Jakun KooSeokhwan BangHye Jin ByunMin-Ji KimKyunga KimKyu-Sung Lee
Keimyung Author(s)
Byun, Hye Jin
Department
Dept. of Urology (비뇨의학)
Journal Title
Sci Rep
Issued Date
2023
Volume
13
Issue
1
Abstract
We performed a prospective, single-arm study comparing outcomes between transurethral ablation plus postoperative instillation of hyaluronic acid and chondroitin sulfate (HACS group) and transurethral ablation only in patients with Hunner type interstitial cystitis (historical control group). A total of 78 patients were enrolled, and 51 were included in the per-protocol analysis set. The 2-year recurrence rate was 47.1% (95% CI, 32.9-61.5) in the HACS group, which was significantly lower than that in the control group (86.2%; 95% CI, 74.6-93.9, P < 0.001). After instillation therapy, the hazard ratio for recurrence was 0.38 (95% CI, 0.23-0.65, P < 0.001). The HACS group had an increased recurrence-free survival with the median interval not being reached, while it was 11.4 months in the control group (95% CI, 8.8-13.8, P < 0.001). Regardless of the instillation treatment, there were significant improvements in all symptom questionnaire scores and pain compared to the baseline. However, in the instillation group, improvement was stable even after 12 months. In patients with Hunner type interstitial cystitis, intravesical instillation of hyaluronic acid and chondroitin sulfate after transurethral ablation significantly reduced the recurrence rate and maintained symptom improvement for more than 1 year.
Keimyung Author(s)(Kor)
변혜진
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-023-44894-x
DOI
10.1038/s41598-023-44894-x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45569
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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