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The effect of donor against recipient one-way HLA mismatch on liver transplantation outcomes from a multicenter registry analysis

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Author(s)
Sunghae ParkYoung Rok ChoiDong Jin JooYoung Kyoung YouBong-Wan KimYang Won NahJai Young ChoTae-Seok KimGeun HongMan Ki JuSuk-Won SuhJae Do YangPyoung Jae ParkJaehong JeongJu Ik MoonDong-Sik KimJinsoo Rhu
Keimyung Author(s)
Kim, Tae Seok
Department
Dept. of Surgery (외과학)
Journal Title
Sci Rep
Issued Date
2023
Volume
13
Issue
1
Abstract
Donor against recipient one-way Human leukocyte antigen (HLA) mismatch (D → R one-way HLA MM) seemed strongly associated with graft-versus-host disease (GVHD). The aim of this study is to investigate the relevance of D → R one-way HLA MM in outcome of liver transplantation (LT). We retrospectively analyzed 2670 patients in Korean Organ Transplantation Registry database between April 2014 and December 2020. The patients were categorized into two groups whether D → R one-way HLA MM or not and evaluated the outcomes of LT between the two groups. 18 patients were found to be D → R one-way HLA MM. The incidence of GVHD (0.3% vs. 22.2%, p < 0.001) and mortality rate (11.6% vs. 38.9%, p = 0.003) was much higher in D → R one-way HLA MM group. D → R one-way HLA MM at 3 loci was seemed to be strongly associated with the incidence of GVHD (OR 163.3, p < 0.001), and found to be the strongest risk factor for patient death (HR 12.75, p < 0.001). Patients with D → R one-way HLA MM at 3 loci showed significantly lower overall survival (p < 0.001) but there were no significant differences in rejection-free survival and death-censored graft survival. D → R one-way HLA MM at 3 loci not only affects the overall survival of LT patients but also the incidence of GVHD.
Keimyung Author(s)(Kor)
김태석
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-023-49178-y
DOI
10.1038/s41598-023-49178-y
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45570
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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