Drug-Coated Balloon Angioplasty in Patients Undergoing Complex Percutaneous Coronary Intervention
- Author(s)
- Hyun Sung Joh; Woochan Kwon; Doosup Shin; Seung Hun Lee; Young Joon Hong; David Hong; Sang Yoon Lee; Hanbit Park; Sunwon Kim; Sang Yeub Lee; Jin-Sin Koh; Hangyul Kim; Chan Joon Kim; Eun Ho Choo; Hyuck-Jun Yoon; Sang Don Park; Ki-Hyun Jeon; Jang-Whan Bae; Sung Gyun Ahn; Sung Eun Kim; Ki Hong Choi; Taek Kyu Park; Jeong Hoon Yang; Young Bin Song; Joo-Yong Hahn; Seung-Hyuk Choi; Hyeon-Cheol Gwon; Joo Myung Lee
- Keimyung Author(s)
- Yoon, Hyuck Jun
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- JACC Asia
- Issued Date
- 2024
- Volume
- 4
- Issue
- 7
- Keyword
- de novo; drug-coated balloon; drug-eluting stent(s); complex percutaneous coronary intervention
- Abstract
- Background:
There are limited clinical data on drug-coated balloon (DCB)-based percutaneous coronary intervention (PCI) compared with drug-eluting stent (DES)-only PCI in patients with complex coronary artery lesions.
Objectives:
The goal of the current study was to investigate the efficacy of DCB in patients undergoing PCI for complex coronary artery lesions.
Methods:
From an institutional registry of patients with de novo complex coronary artery lesions, 126 patients treated with DCB-based PCI were compared with 234 propensity score–matched patients treated with DES-only PCI. Complex coronary artery lesions were defined as the presence of at least 1 of the following: bifurcation, chronic total occlusion, unprotected left main disease, long lesion ≥38 mm, multivessel disease, lesion requiring ≥3 devices, or severe calcification. The primary endpoint was target vessel failure (TVF) at 2 years, a composite of cardiac death, target vessel–related myocardial infarction, and target vessel revascularization.
Results:
Baseline characteristics were comparable between the 2 groups. DCB-based PCI showed a comparable risk of TVF vs DES-based PCI (7.6% vs 8.1%; HR: 0.81; 95% CI: 0.33-1.99; P = 0.638). The risks of cardiac death (5.0% vs 5.7%; HR: 0.78; 95% CI: 0.24-2.49), target vessel–related myocardial infarction (0.9% vs 1.3%; HR: 2.65; 95% CI: 0.26-27.06), and target vessel revascularization (3.5% vs 2.0%; HR: 1.30; 95% CI: 0.30-5.67) were also comparable between the 2 groups.
Conclusions:
DCB-based PCI showed comparable risks of TVF vs those of DES-only PCI in patients with complex coronary artery lesions. DCB might be considered as a suitable alternative device to DES in patients undergoing complex PCI.
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