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Drug-Coated Balloon Angioplasty in Patients Undergoing Complex Percutaneous Coronary Intervention

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Author(s)
Hyun Sung JohWoochan KwonDoosup ShinSeung Hun LeeYoung Joon HongDavid HongSang Yoon LeeHanbit ParkSunwon KimSang Yeub LeeJin-Sin KohHangyul KimChan Joon KimEun Ho ChooHyuck-Jun YoonSang Don ParkKi-Hyun JeonJang-Whan BaeSung Gyun AhnSung Eun KimKi Hong ChoiTaek Kyu ParkJeong Hoon YangYoung Bin SongJoo-Yong HahnSeung-Hyuk ChoiHyeon-Cheol GwonJoo Myung Lee
Keimyung Author(s)
Yoon, Hyuck Jun
Department
Dept. of Internal Medicine (내과학)
Journal Title
JACC Asia
Issued Date
2024
Volume
4
Issue
7
Keyword
de novodrug-coated balloondrug-eluting stent(s)complex percutaneous coronary intervention
Abstract
Background:
There are limited clinical data on drug-coated balloon (DCB)-based percutaneous coronary intervention (PCI) compared with drug-eluting stent (DES)-only PCI in patients with complex coronary artery lesions.

Objectives:
The goal of the current study was to investigate the efficacy of DCB in patients undergoing PCI for complex coronary artery lesions.

Methods:
From an institutional registry of patients with de novo complex coronary artery lesions, 126 patients treated with DCB-based PCI were compared with 234 propensity score–matched patients treated with DES-only PCI. Complex coronary artery lesions were defined as the presence of at least 1 of the following: bifurcation, chronic total occlusion, unprotected left main disease, long lesion ≥38 mm, multivessel disease, lesion requiring ≥3 devices, or severe calcification. The primary endpoint was target vessel failure (TVF) at 2 years, a composite of cardiac death, target vessel–related myocardial infarction, and target vessel revascularization.

Results:
Baseline characteristics were comparable between the 2 groups. DCB-based PCI showed a comparable risk of TVF vs DES-based PCI (7.6% vs 8.1%; HR: 0.81; 95% CI: 0.33-1.99; P = 0.638). The risks of cardiac death (5.0% vs 5.7%; HR: 0.78; 95% CI: 0.24-2.49), target vessel–related myocardial infarction (0.9% vs 1.3%; HR: 2.65; 95% CI: 0.26-27.06), and target vessel revascularization (3.5% vs 2.0%; HR: 1.30; 95% CI: 0.30-5.67) were also comparable between the 2 groups.

Conclusions:
DCB-based PCI showed comparable risks of TVF vs those of DES-only PCI in patients with complex coronary artery lesions. DCB might be considered as a suitable alternative device to DES in patients undergoing complex PCI.
Keimyung Author(s)(Kor)
윤혁준
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2772-3747
Source
https://www.sciencedirect.com/science/article/pii/S2772374724001455
DOI
10.1016/j.jacasi.2024.04.007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45736
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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