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Inappropriate Peak Inspiratory Flow Rate in the Patients with Stable Chronic Obstructive Pulmonary Disease in Korea

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Author(s)
Seong Hwan YounHyun Jung KimJae Seok ParkSun Hyo ParkYong Shik KwonMi-Ae Kim
Keimyung Author(s)
Kim, Hyun JungPark, Jae SeokPark, Sun HyoKim, Mi Ae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Tuberc Respir Dis
Issued Date
2024
Volume
87
Issue
4
Keyword
Inspiratory FlowDry Power InhalerChronic Obstructive Pulmonary DiseaseIn-Check DialInhalerPeak Inspiratory Flow Rate
Abstract
Background:
While inhalation therapy efficacy hinges on attaining proper peak inspiratory flow rate (PIFR), the prevalence of inappropriate PIFR among patients with chronic obstructive pulmonary disease (COPD) remains unstudied in Korea. This study aimed to assess the prevalence of inappropriate PIFR, its correlation with COPD assessment test (CAT) scores, and factors associated with suboptimal PIFR.

Methods:
We enrolled 108 patients with COPD who had been using the same inhaler for at least 1 year without exacerbations. PIFR was measured using an inspiratory flow meter (In-Check DIAL G16). Demographic, clinical, pulmonary function, and CAT score data were collected. Inappropriate was defined as PIFR <60 L/min for dry power inhaler (DPI) users, and >90 L/min for aerosol device users.

Results:
The cohort comprised 87 (80.6%) men, mean age 71.0±8.5 years, with mean post-bronchodilator forced expiratory volume in 1 second of 69.1%±1.8% predicted. Twenty-nine (26.9%) used aerosol devices only, 76 (70.4%) used DPIs only, and three (2.8%) used both. Inappropriate PIFRs were found in 17.2% of aerosol device users, and 42.1% of DPI users. CAT scores were significantly higher in the inappropriate PIFR group than in the appropriate PIFR group (11.2±7.7 vs. 7.5±4.9, p=0.003). In DPI users, female, shorter height, lower body weight and maximal voluntary ventilation (MVV) were associated with inappropriate PIFR.

Conclusion:
The prevalence of inappropriate PIFR among patients with COPD is 17.2% for aerosol device users, and 42.1% for DPI users. Suboptimal PIFR correlates with female gender, shorter stature, lower weight and MVV in DPI users.
Keimyung Author(s)(Kor)
김현정
박재석
박순효
김미애
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1738-3536
Source
https://www.e-trd.org/journal/view.php?doi=10.4046/trd.2023.0195
DOI
10.4046/trd.2023.0195
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45845
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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