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Photobiomodulation Therapy at 660 nm Inhibits Hippocampal Neuroinflammation in a Lipopolysaccharide-Challenged Rat Model

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Author(s)
Tae-Mi JungJong-Ha LeeJin-Chul HeoChang-Hyun Kim
Keimyung Author(s)
Kim, Chang Hyun
Department
Dept. of Neurosurgery (신경외과학)
Journal Title
Biomedicines
Issued Date
2024
Volume
12
Issue
11
Keyword
photobiomodulation therapylow-level light therapyhippocampusbrain inflammation
Abstract
Background/Objectives:
Neuroinflammation is associated with the progression of various brain diseases, and the management of neuroinflammation-induced neural damage is a crucial aspect of treating neurological disorders. This study investigated the anti-inflammatory efficacy of photobiomodulation therapy (PBMT) using 660 nm phototherapy in a rat model with lipopolysaccharide (LPS)-induced neuroinflammation.

Methods:
We induced inflammation in rat brains via intraperitoneal injection of LPS and subjected the treatment group to 660 nm phototherapy to examine its protective effect against hippocampal damage based on pathological, histological, and immunohistochemical tissue analyses.

Results:
The 660 nm treated rats showed a significant decrease in hippocampal structural damage and cell death compared to the LPS-treated group. We observed reduced expression of the inflammation markers GFAP, TNF-α, and IL-1β in the hippocampus of the treatment group, and an increase in SIRT1 expression across all hippocampal regions.

Conclusions:
This study presents a promising method for controlling neuroinflammation and providing neuroprotection and inflammation relief. PBMT represents a non-invasive therapeutic approach with minimal side effects ensured through the proper control of light irradiation.
Keimyung Author(s)(Kor)
김창현
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2227-9059
Source
https://www.mdpi.com/2227-9059/12/11/2514
DOI
10.3390/biomedicines12112514
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/46001
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
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