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Beta-blockers after percutaneous coronary intervention for acute myocardial infarction and non-reduced left ventricular ejection fraction

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Author(s)
Jun-Chang JeongJong-Il ParkByung-Jun KimHong-Ju KimKang-Un ChoiJong-Ho NamChan-Hee LeeJang-Won SonJong-Seon ParkSung-Ho HerKi-Yuk ChangTae-Hoon AhnMyung-Ho JeongSeung-Woon RhaHyo-Soo KimHyeon-Cheol GwonIn-Whan SeongKyung-Kuk HwangSeung-Ho HurKwang-Soo ChaSeok-Kyu OhJei-Keon ChaeUng Kim
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Front Cardiovasc Med
Issued Date
2024
Volume
11
Keyword
beta-blockersmyocardial infarctionpercutaneous coronary interventionleft ventricular ejection fractionpatient-oriented composite endpoints
Abstract
Background:
Data on the clinical impact of beta-blockers (BBs) in patients with myocardial infarction (MI) who had non-reduced left ventricular ejection fraction (LVEF) after percutaneous coronary intervention are limited.

Methods:
From 2016 to 2020, we evaluated a cohort of 12,101 myocardial infarction patients with a non-reduced LVEF (≥40%) from the Korean Acute Myocardial Infarction Registry V. Patients were divided into two groups based on their BB (carvedilol, bisoprolol, or nebivolol) treatment at discharge: with beta-blocker treatment (BB, n = 9,468) and without beta-blocker treatment (non-BB, n = 2,633). The primary endpoint after discharge was the occurrence of patient-oriented composite endpoints (POCEs), including all-cause mortality, any MI, or any revascularization at 1-year follow-up.

Results:
The median follow-up period was 353 days (interquartile range, 198–378 days). At 1-year follow-up, no significant differences were observed in the primary endpoint between the BB group and the non-BB group. Before propensity score (PS) matching, the POCE incidence was 3.1% in the BB group vs. 3.4% in the non-BB group [hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.68–1.09, p = 0.225]. After PS matching, the POCE incidence remained similar between the two groups (3.7% vs. 3.4%, HR 1.01, 95% CI 0.76–1.35, p = 0.931). Individual outcomes, including all-cause mortality, myocardial infarction, and revascularization, also showed no significant differences between the two groups. Independent predictors of 1-year POCEs after discharge were age, chronic kidney disease, reduced LVEF, and multivessel disease.

Conclusion:
BB treatment in patients with acute MI and non-reduced LVEF was not associated with a significant reduction in cardiovascular outcomes at 1-year follow-up.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2297-055X
Source
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1447952/full
DOI
10.3389/fcvm.2024.1447952
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/46010
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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