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Identification of Adipsin as a Biomarker of Beta Cell Function in Patients with Type 2 Diabetes

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Author(s)
Jae-Hyung ParkThi Nhi NguyenHye Min ShimGyeong Im YuEun Yeong HaHochan Cho
Keimyung Author(s)
Park, Jae HyungHa, Eun YeongCho, Ho Chan
Department
Dept. of Physiology (생리학)
Dept. of Internal Medicine (내과학)
Journal Title
J Clin Med
Issued Date
2024
Volume
13
Issue
23
Keyword
adipsinbiomarkerbeta cellstype 2 diabetes
Abstract
Background/Objectives:
Adipsin, an adipokine, is known to play an important role in maintaining the function of pancreatic beta cells in mice. This study aimed to investigate whether adipsin could be a circulating biomarker for evaluating the function of beta cells in patients with type 2 diabetes (T2D).

Methods:
Plasma adipsin concentrations were measured using immunoassay in three distinct subject groups: normoglycemia, T2D without insulin treatment (T2D-w/o-insulin), and T2D treated with insulin (T2D-with-insulin). Adipsin expressions were evaluated in three distinct mouse groups: normal diet (ND), high-fat diet (HFD), and HFD with streptozotocin (STZ) and nicotinamide (NA).

Results:
The T2D-with-insulin group exhibited a significant decrease in plasma adipsin concentration (3.91 ± 1.51 μg/mL) compared to the T2D-w/o-insulin group (5.11 ± 1.53 μg/mL; p < 0.001), whereas the T2D-w/o-insulin group showed a significantly increased plasma adipsin concentration compared to the normoglycemia group (4.53 ± 1.15 μg/mL). Plasma adipsin concentration was positively correlated with fasting C-peptide level (p < 0.001), 2-h C-peptide level (p < 0.001), and 2-h C-peptidogenic index (p < 0.001) in the diabetic groups. HFD mice showed a significant increase in pancreatic islet size, plasma insulin and adipsin levels, as well as adipsin expression in white adipose tissue (WAT) compared to ND mice. In contrast, the insulin-deficient T2D model (HFD-STZ-NA) demonstrated a marked reduction in pancreatic islet size, plasma insulin and adipsin concentrations, and adipsin expression in WAT compared to the HFD mice.

Conclusions:
plasma adipsin may be useful for evaluating pancreatic beta cell function in patients with T2D
Keimyung Author(s)(Kor)
박재형
하은영
조호찬
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/13/23/7351
DOI
10.3390/jcm13237351
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/46020
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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