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Maternal and Neonatal Outcomes Based on Changes in Glycosylated Hemoglobin Levels During First and Second Trimesters of Pregnancy in Women with Pregestational Diabetes: Multicenter, Retrospective Cohort Study in South Korea

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Author(s)
Mi Ju KimSuyeon ParkSooran ChoiSubeen HongJi-Hee SungHyun-Joo SeolJoon Ho LeeSeung Cheol KimSae-Kyoung ChoiJi Young KwonSeung Mi LeeSe Jin LeeHan-Sung HwangGi Su LeeHyun Soo ParkSoo-Jeong LeeGeum Joon ChoJin-Gon BaeWon Joon SeongHyun Sun Ko
Keimyung Author(s)
Bae, Jin Gon
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Life (Basel)
Issued Date
2024
Volume
14
Issue
12
Keyword
first trimesterglycosylated hemoglobinmaternal outcomesneonatal outcomespregestational diabetessecond trimester
Abstract
This study compared glycosylated hemoglobin (HbA1c) levels in the first and second trimesters of pregnancy and assessed maternal and neonatal outcomes according to HbA1c variations among women with pregestational diabetes. This retrospective, multicenter Korean study involved mothers with diabetes who had given birth in 17 hospitals. A total of 292 women were divided into three groups based on HbA1c levels during the first and second trimesters: women with HbA1c levels maintained at <6.5% (well-controlled [WC] group); women with HbA1c ≥ 6.5% (poorly-controlled [PC] group); and women with HbA1c ≥ 6.5% in the first trimester but <6.5% in the second trimester (improved-control [IC] group). The PC group had the highest pregnancy-associated hypertension (PAH) incidence, while the incidence did not significantly differ between the WC and IC groups. The receiver operating characteristic (ROC) curve indicated that HbA1c in the second trimester could predict PAH with a cut-off value of 5.7%. The PC versus WC versus IC group showed statistically significantly higher neonatal birthweight and significantly higher rates of large for gestational age (LGA); however, those were not significantly different between the WC and IC groups. HbA1c levels in the second trimester could predict LGA, with a cut-off value of 5.4%. Therefore, the second trimester HbA1c levels were significantly associated with both maternal and neonatal outcomes.
Keimyung Author(s)(Kor)
배진곤
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2075-1729
Source
https://www.mdpi.com/2075-1729/14/12/1575
DOI
10.3390/life14121575
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/46030
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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