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Comparison of Tegoprazan and Lansoprazole in Patients With Erosive Esophagitis up to 4 Weeks: A Multi-Center, Randomized, Double-Blind, Active-Comparator Phase 4 Trial

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Author(s)
Cheol Min ShinSuck Chei ChoiJin Woong ChoSeung Young KimOk Jae LeeDo Hoon KimYu Kyung ChoJu Yup LeeSang Kil LeeJeong Eun ShinGwang Ha KimSeon-Young ParkSu Jin HongHye-Kyung JungSang Jin LeeYoung Hoon YounSeong Woo JeonIn Kyung SungMoo In ParkOh Young Lee
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Neurogastroenterol Motil
Issued Date
2025
Volume
37
Issue
1
Abstract
Background:
The aims of this study were to confirm the non-inferiority of tegoprazan to lansoprazole up to week 4 in patients with erosive esophagitis (EE) and to evaluate its effectiveness in rapid mucosal healing and symptom relief at week 2.

Methods:
In this multi-center, randomized, double-blind, active-comparator non-inferiority trial, 218 patients with endoscopically confirmed EE (Los Angeles Classification Grades A–D) were randomly allocated to either the tegoprazan (50 mg) or lansoprazole (30 mg) group. The primary endpoint was the cumulative proportion of patients with healed EE up to week 4, as confirmed through endoscopy. The proportion of patients with healed EE at week 2 was also evaluated. Furthermore, CYP2C19 genotypes, symptoms, safety, and tolerability were assessed.

Key Results:
In the full-analysis set, 103 and 109 participants in the tegoprazan and lansoprazole groups, respectively, were analyzed. The cumulative healing rates up to week 4 were 95.2% (98/103) and 86.2% (94/109) (difference [95% confidence interval], 8.91 [1.22–16.59]; p < 0.0001 for non-inferiority and 0.0266 for superiority), while those at week 2 were 88.4% (91/103) and 82.6% (90/109) (5.78 [−3.66–15.22], p = 0.0005 for non-inferiority) for tegoprazan and lansoprazole, respectively. Tegoprazan showed consistent healing rates regardless of CYP2C19 genotypes.

Conclusions and Inferences:
Tegoprazan was superior to lansoprazole in the treatment of EE up to 4 weeks. Further studies are necessary to confirm these findings and clarify the superiority of tegoprazan, especially in the treatment of severe EE.
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1365-2982
Source
https://onlinelibrary.wiley.com/doi/10.1111/nmo.14969
DOI
10.1111/nmo.14969
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/46036
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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