The intricate interactions between inflammasomes and bacterial pathogens: Roles, mechanisms, and therapeutic potentials

Abstract

4-HNE4-hydroxynonenalAIM2absent in melanoma 2ALIacute lung injuryAMPKAMP-activated protein kinaseASCapoptosis-associated speck-like protein containing a caspase recruitment domainATPadenosine triphosphateCARDcaspase recruitment domainCARDScommunity-acquired respiratory distress syndromeCDClostridioides difficileCGRPcalcitonin gene-related peptidecryo-EMcryo-electron microscopyERendoplasmic reticulumFMFFamilial Mediterranean feverGASGroup A StreptococcusGBPsguanylate-binding proteinsGSDMDgasdermin DHDACshistone deacetylaseshGBPhuman GBP1IECsintestinal epithelial cellsIFN-γinterferon-γILinterleukinIFN-Itype I IFNJNKJun N-terminal kinaseKOknockoutKPKlebsiella pneumoniaeLLOlisteriolysin OLMListeria monocytogenesLncenc1long noncoding RNA embryonic stem cells expressed 1lncRNAlong noncoding RNALPLegionella pneumophilaLPSlipopolysaccharideLRRleucine-rich repeatLTlethal toxinMAMsmitochondria-associated membranesMDA5melanoma differentiation factor 5MDRmultidrug resistantMEG3–4maternally expressed gene 3 transcript 4miRNAsmicroRNAsMLKLmixed lineage kinase-likeMtbMycobacterium tuberculosismtDNAmitochondrial DNAmtROSmitochondrial reactive oxygen speciesNAIPsneuronal apoptosis inhibitory proteinsNCOA6nuclear receptor coactivator 6NEK7NIMA-related kinase 7NF-κBnuclear factor-κBNLRCsnucleotide-binding oligomerization domain-like receptor C proteinsNLRPsnucleotide-binding oligomerization domain-like receptorsNLRsNOD-like receptorsNODnucleotide oligomerization domainNSPsneutrophil serine proteasesOMVsouter membrane vesiclesPAPseudomonas aeruginosaPakp21-activated kinasesPAMPspathogen-associated molecular patternsPDHKpyruvate dehydrogenase kinaseRIPKreceptor interacting serine/threonine kinasePKCδprotein kinase C-deltaROSreactive oxygen speciesPRKprotein kinase C-like kinasePTMposttranslational modificationPYDpyrin domainSARS-CoV-2severe acute respiratory syndrome coronavirus 2SPI-1Salmonella pathogenicity island 1STINGstimulator of interferon genesSTECShiga-toxigenic E. coliSUMOsmall ubiquitin-like modifierThT helperT3SStype 3 secretion systemT4SStype IV secretion systemTLRtoll-like receptorTNFtumor necrosis factorTREM2triggering receptors expressed on myeloid cells 2TRIFTIR domain-containing adapter moleculeTRIM28tripartite motif-containing protein 28WTwild-typeXISTX inactivate-specific transcriptZAKαleucin-zipper and sterile-α motifZbp1Z-DNA-binding protein 1