CHEK1 expression was associated with the prognosis in colon cancers

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, yet the molecular determinants of its progression are not fully understood. Although CHEK1 overexpression has been associated with poor prognosis in several malignancies, its role in CRC remains unclear. This study aimed to investigate the clinical and prognostic value of the CHEK1 gene in CRC. CHEK1 expression was analyzed across various cancer types, and its prognostic significance in CRC was further evaluated using data from The Cancer Genome Atlas (TCGA). Higher CHEK1 expression was associated with age in rectal cancer patients and correlated with early pathological stage, N0 stage, M0 stage, anatomic neoplasm type, and MSI status in colon cancer. Survival analysis revealed that higher CHEK1 expression was significantly associated with favorable prognosis in colon cancer. However, in rectal cancer, the association was not statistically significant, likely due to the small sample size. These findings suggest that CHEK1 may be potential as a prognostic biomarker in CRC, and further studies are warranted to elucidate its molecular mechanisms and prognostic implications