섭식 및 절식상태가 방사성초산의 지방조직에의 편입에 미치는 영향

Abstract

To examine the effect of starvation on the incorporation of acetate-1-14C into adipose tissue, male rats weighing approximately 250 gm were divided into two groups; the control group was fed commercial diet ad libitum and the starved group was fasted for 24 hours before the adminis-tration of acetate-1-14C. A single dose of 4 μCi of acetate-1-14C per 100 gm body weight was injected abdominally in both fed and fasted rats. To determine the rate of incorporation of acetate-1-14C into lipid, rats were killed at 1.5, 3.0 and 4.5 hours after the injection, and the radioactivity of labeled lipid was counted with gas flow counter. The incorporation of acetate-1-14C into lipid was the same rate in both mesenteric and the epididy-mal adipose tissue. The rate of acetate-1-14C incorporation into adipose tissue was reached to the peak at three hours after the injection of the acetate regardless of feeding or fasting state. The peak of the acetate incorporation into adipose tissue of starved rate was only one fourth compared with that of normal fed group. The above reaults indicate that lipogenesis in the adipose tissue is remarkablly inhibited by the starvation.