유방암환자에서 nm23 단백 발현양상과 예후인자 및 생존율과의 연관성

Other Titles
Expression of nm23 Protein and its Prognostic Significance in Breast Cancer
Authors
김태국정기용
Department
Dept. of Surgery (외과학)
Issue Date
2003
Citation
Keimyung Medical Journal, Vol.22(2) : 161-167, 2003
Abstract
There are many prognostic factors in breast cancer. Metastasis to the regional lymph nodes in breast cancer patients is the most important prognostic factor. In cases with no metastasis to the regional lymph nodes, tumor size, differentiation, nuclear grade, estrogen receptor (ER) and progesterone receptor (PR) expression, and expression of oncogenes have been reported as prognostic factors. nm23 Gene and its products are known to be inversely related to the potentials of metastasis in breast cancer, however the contradicting results have also been reported. The expression of nm23 protein by immunohistochemical stain was investigated in 61 breast cancer patients and analyzed in relation to other prognostic factors and survival rate. The nm23 protein was positively stained in 91.8% of the breast cancer specimens. The expression of nm23 protein was positively related to the pathologic stage but it was not statistically significant. The expression of nm23 protein was not correlated with 5-year survival rate. In conclusion, the expression of nm23 protein by immunohistochemical method in breast cancer patients was not shown to have any correlation to the pathologic stage and the survival rate.
Keywords
Breast cancerNm23 ProteinSurvival rate
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15277
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2003
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
Keimyung Author(s)
정기용
File in this Item
22-161.pdf(462.31 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE