Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders

Authors
In Seuk JeungSoyoung LeeHeung Sik KimChang Ki Yeo
Department
Dept. of Rehabilitation Medicine (재활의학); Dept. of Pediatrics (소아청소년학); Dept. of Otorhinolaryngology (이비인후과학)
Issue Date
2012
Citation
Annals of Rehabilitation Medicine, Vol.36(3) : 340-346, 2012
ISSN
2234-0645
Abstract
Objective To determine the 9 month period eff ect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualifi ed parent/caregiver-administered questionnaires. Method A total of 17 patients (age 7.6±4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. Th e Drooling Count (DC) was assessed as an objective measurement. Th e Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance. Results DC, DFS and TDS showed signifi cant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value. Conclusion Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and eff ective method to treat sialorrhea in children with neurologic disorders. Key Words Sialorrhea, Botulinum toxin, Salivary gland, Children, Neurologic disorder
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35028
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
Keimyung Author(s)
이소영; 김흥식; 여창기
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