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Association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with overweight/obesity in a Korean population

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Affiliated Author(s)
정인성신동훈하은영박재형배재훈송대규
Alternative Author(s)
Chung, In SungShin, Dong HoonHa, Eun YoungPark, Jae HyungBae, Jae HoonSong, Dae Kyu
Journal Title
Inflammation Research
ISSN
1023-3830
Issued Date
2011
Abstract
Objective Obesity is characterized by the activation of an
inflammatory process leading to an increase in proinflammatory
cytokines and adipokines. This study was designed
to investigate the genetic association between tumor
necrosis factor-a (TNF-a) polymorphisms and the risk of
obesity in the Korean population.
Methods Three single nucleotide polymorphisms [G-238A
(rs361525), C-857T (rs1799724), and C-863A (rs1800630)]
in the promoter region of TNF-a gene were analyzed in 123
control [body mass index (BMI) between 18 and 23] and 208
overweight/obese (BMI C 23) subjects.
Results The mean values of BMI in the control and overweight/
obese groups were 21.1 ± 1.4 and 25.4 ± 1.8,
respectively. Of the three SNPs, G-238A presented a significant
association with overweight/obesity in the
codominant model; the frequency of the G/G genotype in
the overweight/obese group was 9.3%higher than that in the
control group (P = 0.0046). When control and overweight/
obesity subjects were combined together and analyzed, the
level of high-density lipoprotein (HDL) was significantly
higher in the C-857T C/C type SNP (P\0.05).
Conclusions The results of this study suggest that the G
allele of G-238A in TNF-a gene may be a risk factor for
overweight/obesity in the Korean population and that the C
allele of C-857T may be an protective factor in relation to
the HDL level in the general Korean population.
Keywords Body mass index Tumor necrosis factor
Obesity/overweight Polymorphism
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