Nicorandil reduces burn wound progression by enhancing skin blood flow

Authors
Jaehoon ChoiRyeolwoo KimJunhyung KimWoonhyeok JeongSang Woo ParkHyoun Wook LeeHo Yun Chung
Department
Dept. of Plastic Surgery (성형외과학)
Issue Date
2018
Citation
Journal of Plastic, Reconstructive & Aesthetic Surgery, Vol.71(8) : 1196-1206, 2018
ISSN
1878-0539
Abstract
We assessed whether nicorandil, an adenosine triphosphate–sensitive K + channel opener, reduces burn wound progression in a rat comb burn model. A total of 24 rats were used. Following thermal injury, one dose of nicorandil (10 or 30 mg/kg) was administered intra- gastrically twice daily for 3 days. At days 1 and 3 after injury, skin was harvested for histopatho- logical examination and protein isolation. Rats treated with the 10-mg/kg and 30-mg/kg doses of nicorandil exhibited significantly increased tissue survival in the zone of stasis at days 1 and 3 after injury. The 10-mg/kg and 30-mg/kg nicorandil doses also significantly increased skin perfusion in the zone of stasis at days 1 and 3 after injury. At 30 mg/kg, nicorandil significantly reduced hypoxia-inducible factor-1 αexpression in the zone of stasis at day 1 after injury and reduced inflammatory responses in the zone of stasis. The latter effect included decreased polymorphonuclear neutrophil leukocyte infiltration and interleukin-1 βrelease at day 1 after injury. At 30 mg/kg, nicorandil also significantly reduced expression of nuclear factor- κB p65, akey transcriptional factor in the regulation of inflammatory mediators, in the zone of stasis at day 1 after injury. Our study demonstrates that a 30 mg/kg dosing schedule of nicorandil increases tissue survival in the zone of stasis by attenuating ischemia–reperfusion injury. This effect is mediated by the enhancement of skin blood flow and reduction in the inflammatory response. Therefore, our findings suggest that nicorandil has potential clinical applications for patients with burns.
Keywords
NicorandilZone of stasisComb burnBurn wound progression
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41713
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
Keimyung Author(s)
최재훈; 김렬우; 김준형; 정운혁
Full Text
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1748681518301232?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1748681518301232%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F%3Fterm%3D29748072
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