계명대학교 의학도서관 Repository

The cellular function of SCAP in metabolic signaling

Metadata Downloads
Author(s)
Sun Hee LeeJae-Ho LeeSeung-Soon Im
Publication Year
2020
Abstract
Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a key regulator of SREBP maturation. SCAP induces translocation of SREBP from the endoplasmic reticulum to the Golgi apparatus, allowing it to regulate cellular triglyceride and cholesterol levels. Previous studies have shown that suppression of SREBP activation in SCAP conditional knockout mice reduced the accumulation of intracellular triglycerides, which eventually causes the development of metabolic diseases such as atherosclerosis, diabetes, hepatic steatosis, and insulin resistance. However, despite the significance of SCAP as a regulator of SREBP, its function has not been thoroughly discussed. In this review, we have summarized the function of SCAP and its regulatory proteins. Furthermore, we discuss recent studies regarding SCAP as a possible therapeutic target for hypertriglyceridemia and hyperlipidemia.
Department
Dept. of Anatomy (해부학)
Dept. of Physiology (생리학)
Publisher
School of Medicine (의과대학)
Citation
Experimental and Molecular Medicine, Vol.52(null) : 724–729-724–729, 2020
Type
Article
ISSN
2092-6413
DOI
10.1038/s12276-020-0430-0
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42755
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.